Potassium Hydroxide → HCID 19370337, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.6 g of 4-diphenylmethyl-1-[2-(N-ethoxycarbonyl-N-methylamino)ethyl]piperazine (prepared as described in Preparation 35') in 20 ml of a 10% w/v aqueous solution of potassium hydroxide and 20 ml of ethylene glycol was stirred at 140° C. for 20 hours. At the end of this time, the mixture was cooled to room temperature, poured into ice-water and extracted with methylene chloride. The extracts were combined, washed with water and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 1.14 g (yield 88%) of the title compound as an oil.

Provenance & Evidence