HCID 19370367, compound → HCID 19370374, compound

HRID 129760Notes

Reaction equation

HRID 129760 reaction equation
[C:1]1([C:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]#[N:19])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[NH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][C:8](=[C:7]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 19370367HCID 19370367, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19370374HCID 19370374, compoundYield 36%

Procedure

The title compound was prepared in a yield of 36% in a similar manner to that described in Preparation 41' by reacting 4-(diphenylmethylene)-1-(4-cyanobutyl)-piperidine (prepared as described in Preparation 39') and lithium aluminum hydride.

Workup

  1. customdescribed in Preparation 41'
  2. customprepared

Sources & evidence

ORD record
ord-95c0a7b2fa614d6fbde97e30a3fd7a09
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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