6-Formyl-4-methoxy-quinoline-3-carboxylic acid amide → HCID 178493293, compound

HRID 1297613Notes

Reaction equation

HRID 1297613 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]2[O:16][CH3:17])=O.[C:18]1([C@@H:24]2[CH2:26][C@H:25]2[NH:27][C:28]2[S:29][CH2:30][C:31](=[O:33])[N:32]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:17][O:16][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3](/[CH:1]=[C:30]3/[C:31](=[O:33])[N:32]=[C:28]([NH:27][C@@H:25]4[CH2:26][C@H:24]4[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[S:29]/3)[CH:4]=2)[N:9]=[CH:8][C:7]=1[C:13]([NH2:15])=[O:14]

Participants

3

Reactant 2

HCID 585858016-Formyl-4-methoxy-quinoline-3-carboxylic acid amideHCID 178516947HCID 178516947, compound

Product 1

HCID 178493293HCID 178493293, compound

Procedure

Similar procedure as described in example 1g was used, starting from 6-formyl-4-methoxy-quinoline-3-carboxylic acid amide (example 2b) and 2-((1R,2S)-2-phenyl-cyclopropylamino)-thiazol-4-one (example 1f) to give 4-methoxy-6-[4-oxo-2-((1R,2S)-2-phenyl-cyclopropylamino)-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carboxylic acid amide. LC-MS m/e 445 (MH+).

Sources & evidence

ORD record
ord-bbc047a9be8a40d2ae67f98f02cf849c
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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