6-Formyl-4-methoxy-quinoline-3-carboxylic acid amide → HCID 178493294, compound

HRID 1297615Notes

Reaction equation

HRID 1297615 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]2[O:16][CH3:17])=O.[OH:18][CH2:19][C@H:20]([NH:27][C:28]1[S:29][CH2:30][C:31](=[O:33])[N:32]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[OH:18][CH2:19][C@H:20]([NH:27][C:28]1[S:29]/[C:30](=[CH:1]\[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]3[O:16][CH3:17])/[C:31](=[O:33])[N:32]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 585858016-Formyl-4-methoxy-quinoline-3-carboxylic acid amideHCID 178516949HCID 178516949, compound

Product 1

HCID 178493294HCID 178493294, compound

Procedure

Similar procedure as described in example 1g was used, starting from 6-formyl-4-methoxy-quinoline-3-carboxylic acid amide (example 2b) and 2-((R)-2-hydroxy-1-phenyl-ethylamino)-thiazol-4-one (example 3a) to give 6-[2-((R)-2-hydroxy-1-phenyl-ethylamino)-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-methoxy-quinoline-3-carboxylic acid amide. LC-MS m/e 449 (MH+).

Sources & evidence

ORD record
ord-9e108d4de30e47ce820c824f184685fd
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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