6-Formyl-4-methoxy-quinoline-3-carboxylic acid dimethylamide → HCID 178493580, compound

HRID 1297625Notes

Reaction equation

HRID 1297625 reaction equation
[CH3:1][N:2]([CH3:19])[C:3]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[O:15][CH3:16])=[CH:12][C:11]([CH:17]=O)=[CH:10][CH:9]=2)=[O:4].[C:20]1([C@@H:26]2[CH2:28][C@H:27]2[NH:29][C:30]2[S:31][CH2:32][C:33](=[O:35])[N:34]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:1][N:2]([CH3:19])[C:3]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[O:15][CH3:16])=[CH:12][C:11](/[CH:17]=[C:32]1/[C:33](=[O:35])[N:34]=[C:30]([NH:29][C@@H:27]3[CH2:28][C@H:26]3[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[S:31]/1)=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 585857826-Formyl-4-methoxy-quinoline-3-carboxylic acid dimethylamideHCID 178516947HCID 178516947, compound

Product 1

HCID 178493580HCID 178493580, compound

Procedure

Similar procedure as described in example 1g was used, starting from 6-formyl-4-methoxy-quinoline-3-carboxylic acid dimethylamide (example 9c) and 2-((1R,2S)-2-phenyl-cyclopropylamino)-thiazol-4-one (example 1f) to give 4-methoxy-6-[4-oxo-2-((1R,2S)-2-phenyl-cyclopropylamino)-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carboxylic acid dimethylamide. LC-MS m/e 473 (MH+).

Sources & evidence

ORD record
ord-3ca70455b96a4238809f438809297e9c
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…