HCID 58585818, compound → HCID 178466957, compound

HRID 1297627Notes

Reaction equation

HRID 1297627 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=O)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:16]#[N:17])[CH3:2].[OH:18][CH2:19][C@H:20]([NH:27][C:28]1[S:29][CH2:30][C:31](=[O:33])[N:32]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:30]3/[C:31](=[O:33])[N:32]=[C:28]([NH:27][C@H:20]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:19][OH:18])[S:29]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:16]#[N:17])[CH3:2]

Participants

3

Reactant 2

HCID 58585818HCID 58585818, compoundHCID 178516949HCID 178516949, compound

Product 1

HCID 178466957HCID 178466957, compound

Procedure

Similar procedure as described in example 1g was used, starting from 4-ethoxy-6-formyl-quinoline-3-carbonitrile (example 14e) and 2-((R)-2-hydroxy-1-phenyl-ethylamino)-thiazol-4-one (example 3a) to give 4-ethoxy-6-[2-((R)-2-hydroxy-1-phenyl-ethylamino)-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile. LC-MS m/e 445 (MH+).

Sources & evidence

ORD record
ord-64a359cd23c24b50b1a26d9957647e40
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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