Hydrochloric Acid → 6-[2-Amino-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-4-(piperidin-4-yloxy)-quinoline-3-carbonitrile hydrochloride

Participants

Reaction Steps

To 4-{6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-3-cyano-quinolin-4-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (example 29, 34 mg, 0.071 mmol) was added 4N HCl in dioxane (3 mL). After stirring 30 min and removal of the solvent, ether was added. The solid was collected by filtration and washed with ether and dried to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-(piperidin-4-yloxy)-quinoline-3-carbonitrile hydrochloride. LC-MS m/e 480 (MH+).

Provenance & Evidence