Sodium Acetate → HCID 178496240, compound

HRID 1297657Notes

Reaction equation

HRID 1297657 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])=O.[CH:23]1([NH:26][C:27]2[S:28][CH2:29][C:30](=[O:32])[N:31]=2)[CH2:25][CH2:24]1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH:23]1([NH:26][C:27]2[S:28]/[C:29](=[CH:1]\[C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]4[O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])/[C:30](=[O:32])[N:31]=2)[CH2:25][CH2:24]1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 585858736-Formyl-4-[2-(2-methoxy-ethoxy)-ethoxy]-quinoline-3-carbonitrileHCID 178516935HCID 178516935, compound

Product 1

HCID 178496240HCID 178496240, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 28c was used, starting from 6-formyl-4-[2-(2-methoxy-ethoxy)-ethoxy]-quinoline-3-carbonitrile (example 30b), 2-cyclopropylamino-thiazol-4-one, sodium acetate and acetic acid to give 6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-[2-(2-methoxy-ethoxy)-ethoxy]-quinoline-3-carbonitrile. LC-MS m/e 439 (MH+).

Sources & evidence

ORD record
ord-9ee45bf40d7649a49ae7d3d9b73bd2d8
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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