Sodium Acetate → HCID 11581652, compound

HRID 1297665Notes

Reaction equation

HRID 1297665 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=O.COC1C=CC(/C=[C:36]2/[C:37]([NH:39][C:40]([S:42]/2)=[NH:41])=[O:38])=CC=1OC1CCCC1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:41][C:40]1[S:42]/[C:36](=[CH:1]\[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]3[O:15][CH2:16][C:17]([F:20])([F:19])[F:18])/[C:37](=[O:38])[N:39]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585870HCID 58585870, compoundHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 11581652HCID 11581652, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 38 was used, starting from 6-formyl-4-(2,2,2-trifluoro-ethoxy)-quinoline-3-carbonitrile (example 43b), pseudothiohydantoin, sodium acetate and acetic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-(2,2,2-trifluoro-ethoxy)-quinoline-3-carbonitrile. LC-MS m/e 379 (MH+).

Sources & evidence

ORD record
ord-0937de92a972497ba07498b980afc224
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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