1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 19370352, compound

HRID 129767Notes

Reaction equation

HRID 129767 reaction equation
Br[CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].[N:15]1[CH:20]=[CH:19][C:18]([CH:21]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:17][CH:16]=1>>[N:15]1[CH:20]=[CH:19][C:18]([CH:21]([N:28]2[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][N:4]3[C:8](=[O:9])[C:7]4=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]4[C:5]3=[O:14])[CH2:30][CH2:29]2)[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 5035634Piperazine, 1-(phenyl-4-pyridinylmethyl)-

Product 1

HCID 19370352HCID 19370352, compoundYield 77%

Procedure

The title compound was prepared in a yield of 77% in a similar manner to that described in Preparation 1' by reacting N-(2-bromoethyl)phthalimide and 4-[α-(4-pyridyl)benzyl]piperazine.

Workup

  1. customdescribed in Preparation 1'

Sources & evidence

ORD record
ord-f61d3b7695494c8082fda60e4762b6da
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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