HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-Cyano-4-hexyl-quinoline-6-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hexylboronic Acid (contains varying amounts of Anhydride) | HCID 351064 | — |
| Reactant | 4-Chloro-3-cyano-6-quinolinecarboxylic acid ethyl ester | HCID 58585823 | — |
| Product | 3-Cyano-4-hexyl-quinoline-6-carboxylic acid ethyl ester | HCID 58585829 | — |
Reaction Steps
Similar procedure as described in example 46d was used, starting from 4-chloro-3-cyano-quinoline-6-carboxylic acid ethyl ester (example 46c), n-hexylboronic acid, sodium carbonate and POPd to give 3-cyano-4-hexyl-quinoline-6-carboxylic acid ethyl ester as a clear oil. LC-MS m/e 311 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250515B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-2718a961e2f940a58b7d0bf8bc502e09 |
| Source note | uspto-grants-2007_07 |