Sodium Acetate → HCID 11624013, compound

HRID 1297689Notes

Reaction equation

HRID 1297689 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[S:15][CH3:16])=O.COC1C=CC(/C=[C:32]2/[C:33]([NH:35][C:36]([S:38]/2)=[NH:37])=[O:34])=CC=1OC1CCCC1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:37][C:36]1[S:38]/[C:32](=[CH:1]\[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]3[S:15][CH3:16])/[C:33](=[O:34])[N:35]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585863HCID 58585863, compoundHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 11624013HCID 11624013, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 38 was used, starting from 6-formyl-4-methylsulfanyl-quinoline-3-carbonitrile (example 55b), pseudothiohydantoin, sodium acetate and acetic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-methylsulfanyl-quinoline-3-carbonitrile. LC-MS m/e 327 (MH+).

Sources & evidence

ORD record
ord-22106c731fbd48418e9006aec51afd42
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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