Ammonia → HCID 11717377, compound

HRID 1297709Notes

Reaction equation

HRID 1297709 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]#[N:21])=[C:13]3[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:6](=[O:8])[N:7]=1.[NH3:28]>CO>[NH2:28][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]#[N:21])=[C:13]3[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68824771HCID 68824771, compound

Product 1

HCID 11717377HCID 11717377, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Similar procedure as described in example 41c was used, starting from 6-(2-methylsulfanyl-4-oxo-4H-thiazol-5-ylidenemethyl)-4-phenyl-quinoline-3-carbonitrile (example 62e), and ammonia in methanol to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-phenyl-quinoline-3-carbonitrile. LC-MS m/e 357 (MH+).

Sources & evidence

ORD record
ord-c80694aeb9b94a1580815ac15271b283
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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