Hydride → HCID 58585776, compound

HRID 1297711Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][C:10]([C:16]#[N:17])=[C:9]2[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)=O)C.[H-]>>[OH:3][CH2:4][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][C:10]([C:16]#[N:17])=[C:9]2[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 166653Hydride

HCID 58585865HCID 58585865, compound

Product 1

HCID 58585776HCID 58585776, compound

Procedure

Similar procedure as described in example 61h was used, starting from 3-cyano-4-pyridin-3-yl-quinoline-6-carboxylic acid ethyl ester (example 63a), and diisobutylaminum hydride to give 6-hydroxymethyl-4-pyridin-3-yl-quinoline-3-carbonitrile. LC-MS m/e 262 (MH+).

Sources & evidence

ORD record: ord-13c703229679459cb7c08dbe1ece5d75
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250515B2

Reaction notes

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