Sodium Acetate → HCID 11639211, compound

HRID 1297717Notes

Reaction equation

HRID 1297717 reaction equation
[CH2:1]([CH:3]([O:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:17]=O)[CH:15]=2)[N:10]=[CH:9][C:8]=1[C:19]#[N:20])[CH2:4][CH3:5])[CH3:2].COC1C=CC(/C=[C:36]2/[C:37]([NH:39][C:40]([S:42]/2)=[NH:41])=[O:38])=CC=1OC1CCCC1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:41][C:40]1[S:42]/[C:36](=[CH:17]\[C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[N:10]=[CH:9][C:8]([C:19]#[N:20])=[C:7]3[O:6][CH:3]([CH2:4][CH3:5])[CH2:1][CH3:2])/[C:37](=[O:38])[N:39]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585802HCID 58585802, compoundHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 11639211HCID 11639211, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 28c was used, starting from 4-(1-ethyl-propoxy)-6-formyl-quinoline-3-carbonitrile (example 64b), pseudothiohydantoin, sodium acetate and acetic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-(1-ethyl-propoxy)-quinoline-3-carbonitrile. LC-MS m/e 367 (MH+).

Sources & evidence

ORD record
ord-27928d52c1854564b9801d3fdca6f697
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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