Sodium Acetate → HCID 11523535, compound

HRID 1297719Notes

Reaction equation

HRID 1297719 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[S:15][CH2:16][CH:17]([CH3:19])[CH3:18])=O.COC1C=CC(/C=[C:35]2/[C:36]([NH:38][C:39]([S:41]/2)=[NH:40])=[O:37])=CC=1OC1CCCC1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:40][C:39]1[S:41]/[C:35](=[CH:1]\[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]3[S:15][CH2:16][CH:17]([CH3:19])[CH3:18])/[C:36](=[O:37])[N:38]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585857HCID 58585857, compoundHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 11523535HCID 11523535, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 28c was used, starting from 6-formyl-4-isobutylsulfanyl-quinoline-3-carbonitrile (example 65b), pseudothiohydantoin, sodium acetate and acetic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isobutylsulfanyl-quinoline-3-carbonitrile. LC-MS m/e 369 (MH+).

Sources & evidence

ORD record
ord-35b49727435e4409b221569d56cbc7c1
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…