Water → HCID 58585789, compound

HRID 1297730Notes

Reaction equation

HRID 1297730 reaction equation
C(OC(=O)[C:5]([CH2:24][CH2:25][CH2:26][CH3:27])([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[N:14]=[CH:13][C:12]=1[C:22]#[N:23])C(OCC)=O)C.[Cl-].[Li+].O>CS(C)=O>[I:21][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]=[CH:13][C:12]([C:22]#[N:23])=[C:11]2[CH2:5][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 3

HCID 962WaterHCID 433294Lithium ChlorideHCID 58585850HCID 58585850, compound

Product 1

HCID 58585789HCID 58585789, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Similar procedure as described in example 71b was used, starting from 2-butyl-2-(3-cyano-6-iodo-quinolin-4-yl)-malonic acid diethyl ester (example 72a), lithium chloride, water, and dimethylsulfoxide to give 6-iodo-4-pentyl-quinoline-3-carbonitrile. LC-MS m/e 351 (MH+).

Sources & evidence

ORD record
ord-8e479fd8f0144006b015d80c5a4720c0
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…