(4-Ethoxy-3-methanesulfonyl-quinolin-6-yl)-methanol → 4-Ethoxy-3-methanesulfonyl-quinoline-6-carbaldehyde

Participants

Reaction Steps

To a solution of (4-ethoxy-3-methanesulfonyl-quinolin-6-yl)-methanol (example 74b, 25.4 m mol) in anhydrous dichloromethane (500 mL), manganese oxide (13.3 g, 152.4 mmol) was added. The reaction mixture was stirred at 25 degrees for 6 hours. After the reaction, the solid was filtered out; the filtrate was concentrated in vacuo. Column chromatography gave 4-ethoxy-3-methanesulfonyl-quinoline-6-carbaldehyde (3.92 g, 55%). LC-MS m/e 280 (MH+).

Provenance & Evidence