HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → 6-Iodo-4-(2-methoxy-ethoxy)-quinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | Potassium hydride | HCID 82127 | — |
| Reactant | 4-Chloro-6-iodoquinoline-3-carbonitrile | HCID 22466769 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Iodo-4-(2-methoxy-ethoxy)-quinoline-3-carbonitrile | HCID 68824431 | — |
Reaction Steps
Similar procedure as described in example 28a was used, starting from 2-methoxy-ethanol, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 6-iodo-4-(2-methoxy-ethoxy)-quinoline-3-carbonitrile. LC-MS m/e 355 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250515B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-dcad2fc8cede4ab2af0b8a5b28052054 |
| Source note | uspto-grants-2007_07 |