Sodium Acetate → HCID 178496146, compound

HRID 1297749Notes

Reaction equation

HRID 1297749 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[O:15][CH2:16][CH2:17][O:18][CH3:19])=O.[CH:20]1([NH:23][C:24]2[S:25][CH2:26][C:27](=[O:29])[N:28]=2)[CH2:22][CH2:21]1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH:20]1([NH:23][C:24]2[S:25]/[C:26](=[CH:1]\[C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]4[O:15][CH2:16][CH2:17][O:18][CH3:19])/[C:27](=[O:29])[N:28]=2)[CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585878HCID 58585878, compoundHCID 178516935HCID 178516935, compound

Product 1

HCID 178496146HCID 178496146, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 28c was used, starting from 6-formyl-4-(2-methoxy-ethoxy)-quinoline-3-carbonitrile (example 77b), 2-cyclopropylamino-thiazol-4-one (example 37c), sodium acetate and acetic acid to give 6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-(2-methoxy-ethoxy)-quinoline-3-carbonitrile. LC-MS m/e 395 (MH+).

Sources & evidence

ORD record
ord-5447a25fd7df44159e7d416cf809f2eb
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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