HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Bromo-o-chlorotoluene → 1-(2-Chloro-benzyl)-7-ethyl-1h-indole-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Bromo-o-chlorotoluene | HCID 11905 | — |
| Reactant | 7-ethyl-2,3-dihydro-1H-indole-2,3-dione | HCID 247365 | — |
| Reactant | 2-tert-butylimino-N,N-diethyl-1-methyl-1,3,2lambda5-diazaphosphinan-2-amine | HCID 19990018 | — |
| Product | 1-(2-Chloro-benzyl)-7-ethyl-1h-indole-2,3-dione | HCID 58914723 | 85% |
Reaction Steps
Using a method similar to Preparation 15, with 7-ethylisatin (88 mg, 0.5 mmol), 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine on polystyrene beads(630-720 mg, 1.4-1.6 mmol, 2.2 mmol/g, Fluka) and 2-chlorobenzyl bromide (0.065 mL, 0.5 mmol) gives 121 mg (85%) of the title compound as crude material as a red-orange solid. MS (ES): m/z=300 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250442B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-72ef6f480ddb4fdd87c80d0992694c21 |
| Source note | uspto-grants-2007_07 |