Hydrochloric Acid → HCID 19370421, compound

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Reaction Steps

0.3 g (7.9 mmol) lithium aluminium hydride is placed in 50.0 ml absolute ether and cooled in the ice bath to 0°-5° C. 1-(4-methoxy-2-methylthiophenyl)-2-(4-methoxyphenyl)ethanon (71) (6.9 mml) is dissolved in absolute ether and slowly added dropwise to the lithium aluminium hydride suspension. Following that it is heated for one hour to boiling point. After cooling, it is hydrolysed carefully with water, and acidified with dilute hydrochloric acid, until all the alumuinium hydroxide has gone into solution. It is extracted three times with ether, washed twice with water, dried over MgSO4, filtered and condensed in a water jet vacuum. The product is purified by column chromatography with silica gel 60 (eluction medium dichloromethane/ether (19:1).

Provenance & Evidence