HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297883Generated: October 30, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1297883
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-iodo-4-(trifluoromethyl)- | HCID 67993 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Catalyst | N,N'-bis(2,4,6-trimethoxyphenyl)ethanediamide | HCID 126500457 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 21.809% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 0% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-bb13ac995b2f461c861172f926856487 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
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