Benzimidazole, 2-butyl- → 4-((2-butyl-1H-benzimidazol-1-yl)-methyl)-benzonitrile

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Reaction Steps

Using the procedure of Step B of Example 1, 3.5 g of 2-butyl-1H-benzimidazol [POOL et al., Am. Soc., Vol. 59, p. 178 (1937)] and 4.3 g of 4-bromomethyl benzonitrile were reacted to obtain 6.8 g of the desired product melting at 130° C. which was dissolved in methylene chloride, treated with activated charcoal, filtered and evaporated to dryness to obtain 6 g of product melting at 130° C. which was crystallized from isopropyl ether to obtain 4.7 g of the expected product melting at 148° C. The analytical sample was obtained by two successive crystallizations of 1.2 g of the product from isopropyl ether to obtain 700 mg of purified product melting at 150° C.

Provenance & Evidence