HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4'[(2-butyl-3H-thieno-(2,3-d)-imidazol-3-yl)-methyl]-(1,1'-biphenyl)-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4'-[(2-butyl-3H-thieno-(2,3-d)-imidazol-3-yl)-methyl]-(1,1'-biphenyl)-2-carboxylate | HCID 19370646 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4'[(2-butyl-3H-thieno-(2,3-d)-imidazol-3-yl)-methyl]-(1,1'-biphenyl)-2-carboxylic acid | HCID 19370629 | 66.3% |
Reaction Steps
Using the procedure of Example 31, 250 mg of the product of Example 30 (isomer B) in 4 ml of methanol and then the addition of 0.3 ml of sodium hydroxide (10N) were reacted to obtain 160 mg of the expected product melting at 203° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05470867 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-6aca16a724f44109ab8360dc77a87d61 |
| Source note | uspto-grants-1995_11 |