反应详情

Mix ethyl 4-iodobutyrate (43.5 g, 0.18 mol), dibenzylamine (35.5 g, 0.18 mol), potassium carbonate (24.9 g, 0.18 mol) and ethanol (114 mL dried over 4A molecular sieves). Reflux for 24 hours then stir at room temperature for 48 hours. Add methylene chloride (100 mL) and filter. Evaporate the filtrate to a residue and purify by silica gel chromatography (methylene chloride) to give the title compound (47 g).

1. temperatureReflux for 24 hours
2. filtrationAdd methylene chloride (100 mL) and filter
3. customEvaporate the filtrate to a residue
4. custompurify by silica gel chromatography (methylene chloride)