HRID129927

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10870595

4H-Thieno[3,2-e]-1,2-thiazin-4-one, 6-chloro-2,3-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide

C10H12ClNO4S2

PRODUCTS

生成物

HCID9926764

(4S)-6-Chloro-4-hydroxy-2-(3-methoxypropyl)-3,4-dihydro-1lambda~6~-thieno[3,2-e][1,2]thiazine-1,1(2H)-dione

C10H14ClNO4S2

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc(B2OC(c3ccccc3)(c3ccccc3)[C@@H]3CCCN23)cc1

催化剂HCID10903897

(3aS)-1,3,3-Triphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole

C23H22BNO

PROCEDURE

实验过程

Starting with 9.3 g of ketone 6 and following the same procedure as mentioned in Example 5 except using a stock solution of 1M (S)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole as catalyst led to 1, 4.9 g (52%) yield, ee=65%.

WORKUP

后处理

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