反应详情

(1,3-Dithiol-2-ylidene)malonic acid dimethyl ester (232 mg) prepared according to the procedure described in JP-76.48666, was suspended in methanol (0.1 ml) and 1N KOH/methanol (3.0 ml) was added. The reaction mixture was refluxed for 1 h and then concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution was adjusted to 2 with 1N HCl. The resulting precipitate was collected by filtration, washed with water, and dried in vacuo to give the title compound (196 mg) as a pale yellow powder.

1. temperatureThe reaction mixture was refluxed for 1 h
2. concentrationconcentrated under reduced pressure
3. dissolutionThe residue was dissolved in water
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with water
6. customdried in vacuo