HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → tert-butyl [(1S)-1-methyl-2-(2-naphthyl)-2-oxoethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate | HCID 11806530 | — |
| Reactant | HCID 178418423 | HCID 178418423 | — |
| Product | tert-butyl [(1S)-1-methyl-2-(2-naphthyl)-2-oxoethyl]carbamate | HCID 59339838 | — |
Reaction Steps
The subtitle compound was prepared analogous to the method described in Example 19 (step 19d), starting from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (1.86 g, 8 mmol) and a freshly prepared 2-Naphthylmagnesiumbromide 1M solution in THF (8 mL, 8 mmol). The obtained material was crystallised from Heptane. Yield 350 mg (14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-94c704e41ce44a75a87597d3c55b1022 |
| Source note | uspto-grants-2010_06 |