HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (S)-tert-butyl 1-(3-ethylphenyl)-1-oxopropan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate | HCID 11806530 | — |
| Reactant | HCID 178436338 | HCID 178436338 | — |
| Product | (S)-tert-butyl 1-(3-ethylphenyl)-1-oxopropan-2-ylcarbamate | HCID 59339663 | — |
Reaction Steps
The subtitle compound was prepared analogous to the method described in Example 19 (step 19d). Starting from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (0.7 g, 3.01 mmol) and freshly made (3-ethylphenyl)magnesium bromide 0.9M solution in THF (5 mL, 4.50 mmol). Yield 817 mg (97%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-99f35be9b4874ec3accc08ee17beeb82 |
| Source note | uspto-grants-2010_06 |