HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1302900Generated: November 2, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1302900
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | 2'-(diphenylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine | HCID 2734939 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 27.79% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 5.363% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-08c7ee4a7d6143e485358db158570db1 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
