HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → tert-butyl (1R,2S)-1-hydroxy-1-m-tolylpropan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate | HCID 11806530 | — |
| Reactant | HCID 178425413 | HCID 178425413 | — |
| Product | tert-butyl (1R,2S)-1-hydroxy-1-m-tolylpropan-2-ylcarbamate | HCID 59339884 | — |
Reaction Steps
The subtitle compound was prepared in two steps analogous to the methods described in Example 19 (step 19c+19d). Starting from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (2.323 g, 10 mmol), and m-tolylmagnesium bromide 1.0M solution in THF (12.00 mL, 12.00 mmol). Yield 2.33 g (88%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-5cf924039e0d424c87afad66d6350ace |
| Source note | uspto-grants-2010_06 |