HCID 11962692, compound → HCID 11962695, compound

Participants

Reaction Conditions

Reaction Steps

100 mg of the ethyl 1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}-1,2,3-triazole-4-carboxylate prepared in Example 4A was dissolved in approximately 10 mL of 1 N KOH in methanol. The solution was stirred at 60° C. for 24 hours. The solvent was then removed and the residue dissolved in 5 mL ethyl acetate. The aqueous phase was brought to a pH of 3-4 by addition of 37% HCL. The resulting solid was collected by filtration and washed with water and ether then air dried to provide the product, 1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}-1,2,3-triazole-4-carboxylic acid.

Provenance & Evidence