Cyclopentylamine → (2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-[6-(cyclopentylamino)-2-iodopurin-9-yl]oxolan-3-yl acetate

関与物質

役割	名称	HCID	仕込み量
反応物	Cyclopentylamine	HCID 2906	—
反応物	Diisopropylethylamine	HCID 81531	—
反応物	Acetic acid (2R,3R,4R,5R)-3,4-diacetoxy-5-(6-chloro-2-iodo-purin-9-YL)-tetrahydro-furan-2-ylmethyl ester	HCID 482588	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	(2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-[6-(cyclopentylamino)-2-iodopurin-9-yl]oxolan-3-yl acetate	HCID 14886862	—

反応手順

1.15 g of [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(6-chloro-2-iodopurin-9-yl)oxolan-2-yl]methyl acetate (Toronto Research Chemicals) was placed in 20 mL of DMF (dimethylformamide) and stirred. To this solution was added 0.42 mL of cyclopentyl amine and 10 mL of DIPEA (diisopropylethylamine). The resulting mixture was stirred overnight at room temperature. The next morning, the solvent was removed and the residue purified using a dichloromethane/methanol 20:1 column to provide (2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-[6-(cyclopentylamino)-2-iodopurin-9-yl]oxolan-3-yl acetate, a compound of formula (10).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07381714B2
出典データセット	uspto-grants-2008_06
ORD ID	ord-61a9967aeaa54b84a6ad1180b491e204
出典メモ	uspto-grants-2008_06