HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1303140Generated: November 1, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1303140
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | 2-(Di-sec-butylphosphino)-N,N-dimethylaniline | HCID 23443513 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 4.6% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 0% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-a372dea0d9bd4f6f9cd19b4c2d4cda1b |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
