反应详情

温度

60 °C

To a mixture of 135.5 mg (0.612 mmol) of the benzoxazinone prepared in Example 6 and glacial acetic acid (2 mL), p-anisidine (0.735 mmol) was added and the reaction mixture was heated to 60° C. for 24 hrs. The reaction mixture was concentrated in vacuo and partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was washed with water, brine, dried over magnesium sulfate, filtered, and concentrated in vacuo to afford the product as a yellow oil (13.7% yield).

1. additionwas added
2. concentrationThe reaction mixture was concentrated in vacuo
3. custompartitioned between ethyl acetate and saturated aqueous sodium bicarbonate
4. washThe organic layer was washed with water, brine
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo