HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxypropanoyl chloride → N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-3-methoxy-propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxypropanoyl chloride | HCID 2759728 | — |
| Reactant | (1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine | HCID 66812640 | — |
| Product | N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-3-methoxy-propanamide | HCID 25014204 | — |
Reaction Steps
Prepared as described in Example 1 using (1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine (1a, 18 mg, 50 μmol) and 3-methoxypropanoyl chloride (18 mg, 150 μmol). Yield 17 mg (74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-99a9f2db2daa41759fc3830d05c7d03e |
| Source note | uspto-grants-2010_06 |