HuagongsheHuagongshe Chemistry Print Report · For research reference only
cis-3,5-Dimethyl-1-[2-(methyloxy)-5-nitrophenyl]piperazine → 3-(cis-3,5-Dimethyl-1-piperazinyl)-4-(methyloxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cis-3,5-Dimethyl-1-[2-(methyloxy)-5-nitrophenyl]piperazine | HCID 59007077 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | 3-(cis-3,5-Dimethyl-1-piperazinyl)-4-(methyloxy)aniline | HCID 59007045 | — |
Reaction Steps
cis-3,5-Dimethyl-1-[2-(methyloxy)-5-nitrophenyl]piperazine (D1) (10 g, 38 mmol) and 10% palladium on charcoal were dissolved in ethanol (200 ml) and hydrogenated at room temperature under an atmosphere hydrogen for 16 hours. The mixture was filtered through celite and the filtrate concentrated in vacuo to afford the title product (D2). MS (ES+) m/e 236 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07381728B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-56ad5d2fabca4eb5bb549ac683b051b9 |
| Source note | uspto-grants-2008_06 |