Thionyl Chloride → 6-(3-Thienyl)-2-pyridinesulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(3-thienyl)-2-pyridinesulfonic acid sodium salt (D9) and N,N-dimethylformamide (1 drop) in thionyl chloride (2 ml) was heated at 70° C. for 2 hours. After cooling to room temperature the solution was concentrated in vacuo and the residue co-evaporated with toluene (×2). The residue was triturated with diethyl ether to afford the title product (D10).

Provenance & Evidence