反应详情

1,3-Dimethoxy-4-nitrobenzene (5.0 g, 27 mmol) in chloroform (50 ml) at 0° C., was treated with a solution of bromine (1.68 ml, 33 mmol) in chloroform (50 ml). The solution was stirred with warming to room temperature for 4 hours, washed with 10% sodium thiosulfate solution and brine then dried over anhydrous magnesium sulfate and concentrated in vacuo. The crude product was used without further purification (D17). MS (ES+) m/e 262/264 [M+H]+.

1. washwashed with 10% sodium thiosulfate solution and brine
2. dry with materialthen dried over anhydrous magnesium sulfate
3. concentrationconcentrated in vacuo
4. customThe crude product was used without further purification (D17)