2-Thiopheneboronic acid → N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-(2-thienyl)benzenesulfonamide

HRID 130462Notes

Reaction equation

HRID 130462 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1B(O)O>>[Br:1][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:25]3[S:24][CH:28]=[CH:27][CH:26]=3)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10]

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 69197676N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-iodobenzenesulfonamide

Product 1

HCID 69198455N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-(2-thienyl)benzenesulfonamide

Procedure

The title compound was prepared from the product of Step 1 and 2-thienylboronic acid using a similar method to that described for Examples 126-196. MS (ES−) m/e 476/478 [M−H]−.

Sources & evidence

ORD record
ord-22921c9bca3e493bbb5765619625b429
Source dataset
uspto-grants-2008_06
Patent number
US07381728B2

Reaction notes

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