Hydrochloric Acid → HCID 59007073, compound

Participants

Reaction Steps

A mixture of the product of Step 1 (205 mg, 0.5 mmol), 2-furanylboronic acid (112 mg, 2 mmol), 1M sodium carbonate solution (2.5 ml, 2.5 mmol) and tetrakis(triphenylphosphine)palladium(0) (58 mg, 0.05 mmol) in 1:1 toluene:ethanol (10 ml) was stirred at reflux under an atmosphere of argon for 1.5 hours. After cooling to room temperature the reaction mixture was acidified with 2N hydrochloric acid and applied to a 10 g SCX column and eluted in methanol then 2M ammonia in methanol. The combined basic fractions were concentrated in vacuo. The crude residue was purified by mass directed autoprep to afford the title product (E272). MS (ES+) 443 [M+H]+.

Provenance & Evidence