HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1305454Generated: November 3, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1305454
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | HCID 178420723 | HCID 178420723 | — |
| Catalyst | HCID 178454875 | HCID 178454875 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 24.245% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 4.95% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-5d113c99dc884a9480ab4806b2b5879f |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
