HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 130579Generated: October 27, 2026
Hydrochloric Acid → 3-Azaspiro(5.5)undecane-2,4-dione
https://huagongshe.com/reaction/130579
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate | HCID 11323033 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 3-Azaspiro(5.5)undecane-2,4-dione | HCID 14324 | 68.5% |
Reaction Steps
10 g of methyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate and 5 g of NaOH dissolved in 125 ml of 2:1 ethanol/water are placed in a 250 ml flask equipped with mechanical agitator, thermometer and condenser. The mixture is heated under reflux for 1.5 hours, acidified with 5% HCl to pH 2 and heated under reflux for 3 hours. By cooling to 20° C. a precipitate is formed which is filtered off, washed with water and dried under vacuum. 4.7 g of 2,4-dioxo-3-azaspiro[5,5]undecane are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07381823B2 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-1b865930ef554f46af6702e236808c8f |
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| Source note | uspto-grants-2008_06 |
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