反应详情

To a solution of α-bromophenylacetic acid (2.15 g, 10 mmol) in ethanol (30 mL) was added 1M HCl in ether (5 mL) and the solution was heated under reflux overnight. The reaction mixture was concentrated to a brown oil (ethyl α-bromophenylacetate), which was used without further purification. A solution of crude ethyl α-bromophenylacetate (2.43 g, 10 mmol) in ethanol (20 mL) was added dropwise to a stirred solution of ethylenediamine (1.2 g, 20 mmol) in 30 mL of ethanol. After the addition was completed, a solution of sodium ethoxide (8.5 mL, 20 mmol, 21 wt. % solution in ethyl alcohol) was added and the reaction was heated under reflux 16 h. The excess ethylenediamine and ethanol were removed under reduced pressure. The residue was extracted with ethyl acetate (200 mL×3), washed with saturated NaCl solution (30 mL×2), dried over MgSO4 and filtered. The crude yellow solid obtained by rotary evaporation of ethyl acetate was purified by silica gel column chromatography. The white solid (1.1 g, 6.2 mmol, 62%) was obtained by elution with CHCl3:MeOH:NH4OH (9:1:0.1). 1H NMR (DMSO-d6): δ 2.75-2.95 (2H, m), 2.95 (1H, br s), 3.10-3.15 (1H, m), 3.21-3.25 (1H, m), 4.29 (1H, s), 7.20-7.37 (5H, m), 7.78 (1H, s). mp: 138°-140° (uncorr.) [lit.]mp: 139°-139.5° (corr.)

1. temperaturethe solution was heated
2. temperatureunder reflux overnight
3. concentrationThe reaction mixture was concentrated to a brown oil (ethyl α-bromophenylacetate), which
4. customwas used without further purification
5. additionAfter the addition
6. temperaturethe reaction was heated
7. temperatureunder reflux 16 h
8. customThe excess ethylenediamine and ethanol were removed under reduced pressure
9. extractionThe residue was extracted with ethyl acetate (200 mL×3)
10. washwashed with saturated NaCl solution (30 mL×2)
11. dry with materialdried over MgSO4
12. filtrationfiltered
13. customThe crude yellow solid obtained by rotary evaporation of ethyl acetate
14. customwas purified by silica gel column chromatography