HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-(2,4-Difluorophenyl)acrylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2,4-Difluorobenzaldehyde | HCID 73770 | — |
| Product | 3-(2,4-Difluorophenyl)acrylic Acid | HCID 603502 | 77% |
Reaction Steps
A disadvantage here is the high reaction temperature needed, the unsatisfactory yield and the difficult accessibility of the compounds of the formula (I). Monatshefte der Chemie 90, 680 (1959) describes the reaction of 2,4-difluorobenzaldehyde with acetic anhydride at 180° C., 2,4-difluoro-cinnamic acid being obtained in a 77% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07381832B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-713f7e8e136d41799a23ae377085f383 |
| Source note | uspto-grants-2008_06 |