反应详情

温度

100 °C

The procedure was as in Example 5, but the 2,4-difluorocinnamic acid obtained was not isolated. The aqueous-acidic product suspension obtained was treated with 2 g of Pd/C (5% strength) at 50° C. with further stirring and heated to 100° C. It was then pressurized to 5 bar of hydrogen. After constant pressure had been achieved, it was cooled to room temperature, the pressure was released and the solid was filtered off. The filter cake was taken up in methylene chloride, the palladium catalyst was filtered off and the solvent was removed. After drying in vacuo, 100.5 g of 3-(2,4-difluorophenyl)propionic acid (90% of theory; melting point: 100° C.) were obtained.

1. customwas not isolated
2. customThe aqueous-acidic product suspension obtained
3. temperatureit was cooled to room temperature
4. filtrationthe solid was filtered off
5. filtrationthe palladium catalyst was filtered off
6. customthe solvent was removed
7. customAfter drying in vacuo