Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1306077노트

반응식

HRID 1306077 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)P(c1ccccc1)C(C)(C)C.CC(C)(C)[O-].COC(=O)C(C)=[CH2]->[Ni](<-[CH2]=C(C)C(=O)OC)[CH]1N(c2c(C(C)C)cccc2C(C)C)CCN1c1c(C(C)C)cccc1C(C)C.COCCOCCOC.[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 17.721%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 5.079%

시약·촉매·용매 4

HCID 23676156Sodium t-butoxide시약HCID 316378Di-tert-butylphenylphosphine촉매HCID 178500470HCID 178500470, 화합물촉매HCID 8150Diglyme용매5회

반응 조건

온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-0fbf841652af4cd199c93e5cea8e0ce5
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
출처 보기

반응 노트

불러오는 중…