HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 11442917, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 11740028 | HCID 11740028 | — |
| Reactant | 2-(2-Bromoethyl)-1-methylpyrrolidine | HCID 59730744 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 11442917 | HCID 11442917 | — |
Reaction Steps
A solution of 25-F (70 mg, 0.19 mmol), 2-(2-bromoethyl)-1-methylpyrrolidine 25-B (110 mg crude and Cs2CO3 (94 mg, 1.5 mmol) in DMSO (2 ml) was heated to 120° C. for 2 hours. The title compound, N,2-dimethyl-6-({6-[2-(1-methylpyrrolidin-2-yl)ethoxy]quinolin-4-yl}oxy)-1-benzothiophene-3-carboxamide 25 (21 mg) was isolated by HPLC (Dionex System) using 20-60% CH3CN/H2O (0.1% AcOH) over 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07381824B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-2105e93169af421db107b88cd7e43b29 |
| Source note | uspto-grants-2008_06 |