1,2-Dibromoethane → HCID 11477177, compound

Participants

Reaction Steps

A solution of 90-G (1.4 g, 3.7 mmol), Br(CH2)2Br 90-H (2.1 g, 11.2 mmol) and K2CO3 (1.5 g, 11.2 mmol) in DMF (40 ml) was heated to 50° C. overnight. The reaction mixture was extracted with EtOAc. The concentrated residue was purified by silica gel column chromatography using 5% MeOH/CH2Cl2 to yield 6-{[7-(2-bromoethoxy)quinolin-4-yl]oxy}-N-cyclopropyl-2-methyl-1-benzofuran-3-carboxamide 90-1 (1.1 g, 61%).

Provenance & Evidence